The end of my loosely-connected trilogy of essays devoted to stories featuring kryptonite in Superman comic books is long-overdue...and really awkwardly put, since why would any non-Superman comic feature a story about kryptonite if it wasn't setting up an appearance by Superman? It's one of the few things that can kill Superman, the irony that it's made from the remains of his home planet; you're killing him with a "souvenir from home".
Kryptonite can be annoying, because it allows for Superman to be in peril of garden-variety gangsters and thugs; why waste imagination coming up with formidable foes for Superman to spar with, when a purse-snatcher holding a green rock the size of a penny could knock him out?
So..you can imagine the conceit in which Cooke has the audacity to suggest that the villain of his tale could be a giant sentient, telepathic chunk of kryptonite that's been passed around over the decades to various owners like the Hope Diamond, only to reveal that it was actually a cage for a telepathic alien imprisoned like a fly in amber, after briefly becoming intangible during Krypton's explosion, then trapped inside the meteorite while phasing in, ultimately using his mental prowess to force gangster Tony Gallo to act as his proxy on behalf, ultimately reforming the psychotic capo in an uneasy puppet show...I $#!+ you not, that's part of the plot in this book.
Superman: Kryptonite is actually the classiest Superman arc I've ever read, but I don't think it caught on with readers the way people say other stories have, like "Red Son" or "Whatever Happened To The Man From Tomorrow?" - but it's good company with those tales on your bookshelf of Superman stories...if you have one. It's got a sci-fi/noir feel to it, only cheapened, in my opinion, by the appearance of the post-Crisis version of Lex Luthor - the boring 1980's business tycoon. Again, just my opinion, but I prefer the Tony Stark version of Lex Luthor that was more prominent in the Silver and Bronze Age, who occasionally appears in Modern Age comics in the last decade since Infinite Crisis. Luthor didn't appear in the original tale that introduced kryptonite and he shouldn't have appeared here, even if it's abundantly clear that the only reason he's in this is to depict a new origin for the infamous kryptonite ring that he wore...which gave him cancer due to being in nonstop close proximity to it's radiation...which resulted in him faking his death and transplanting his conciousness in a cloned body that posed as the original's "son" until the clone body deteriorated and he made a deal with DC's equivalent of the Devil - Neron - in exchange for having his restored...I $#!+ you not, this junk actually happened in the Superman books during the 90's...a character worthy of antics deserving to be banished to the now non-existent "quarter-bins" really shouldn't be seen in a classy joint like Superman: Kryptonite.
What else could've derailed this story? It was used as a launch for a new ongoing comic book series, Superman Confidential, a counterpart to another title, Batman Confidential, which was supposed to be the successor to the venerable 1990's Batman comic Legends of The Dark Knight..
..just as a sidebar, I can't help thinking a book titled Legends of The Man of Steel would've been more interesting to have for an anthology book that was going to offer stories in a similar vein - tales set in the early years of Superman's career - but Coinfiential must've sounded "kewl" to the guys occupying the DC Comics offices at the time...
Batman Confidential lasted a few years, whereas Superman Confidential never got off the ground...this opening arc was plagued with delays (I think Tim Sale was also working on the TV series "Heroes" during this time - 2006) and DC Comics editors tried filling the schedule with mediocre fill-in stories by other writers and artists. That strategy for dealing with late books tends to piss off retailers and fans alike, because too long a wait invariably kills interest and hurts sales. It couldn't have helped that five of the six issues that serialized this story had drab covers. Issue #3 has the best cover - with the giant Kryptonite rock in the background and the "villain", Tony Gallo, in the foreground.
Another problem is that Darwyn Cooke could be his biggest critic. The introduction featured in the hardcover and paperback editions has Cooke somewhat writing apologetically, that brainstorming ideas for a standable Superman story arc that could stand the test of myriad continuity changes and reboots was no picnic and appreciated all the help he got from working with Sale, plus the fact that this tale was a total reboot of a Golden Age tale that was executed frivolously (my observation from Cooke's summation, not necessarily his) and he was grateful to just see it done and in print, at last.
That...bellies the confidence and talent on display, here. All parties involved were up to the task and did a great job. It's one of the best Superman comics I've read. And it's even better collected as a graphic novel. I $#!+ you not.